الفهرس | Only 14 pages are availabe for public view |
Abstract The subject of this thesis is the preparation and characterization of some novel diaryldithiophene and mono hetero and/or dithiophene Derivatives were designed, synthesized under stille coupling reaction conditions and evaluated for their antitumor activities on 3 different cell lines; Breast, Liver and Lung Cancer. Chapter One ”Introduction” : This includes detailed survey of some organometallic complexes and gives a general introduction survey, review and new scientific background of the basic principle theory of palladiumcatalyzed, cross-coupling and oxidative addition reactions including examples for the synthesis of some organometallic complexes related to our work. Chapter Two ”Results and Discussion” : This chapter deals with a detailed study for the synthesis, characterization and describes the strategy of the methods that can be applied to give products in pure form, resulting in the synthesis of a class of compounds by stille coupling reaction process, using different reagents. It includes as well investigating the synthesis of the following compounds 5,5’-di(thiophen-2-yl)biphenyl-2,2’-diol (46) 2,2’-bis-benzyloxy-5,5’-di(thiophen-2-yl)-biphenyl (48) 2,5-di(thiophen-2-yl)pyridine (50) 5-(thiophen-2-yl)pyrimidine-2,4-(1H, 3H)-dione (52) 2-(thiophen-2-yl)quinoline-3- carbaldehyde (54) Biological evaluation and docking study of the prepared compounds Novel diaryldithiophene and mono hetero and/or dithiophene derivatives (46,48,50,52,54) were evaluated for their antitumor activities in 3 different cell line such as, Breast (MCF7), Liver (HEPG2) and Lung Cancer (A549). All Compounds exhibited highly potent cytotoxic activity with IC50 values in 0.042 – 4.09 μM range. Also molecular docking study was carried out using complex (H10V) as template to predict the binding affinity of the target compounds to the receptor. Chapter Three ”Experimental” : This incudes detailed experimental work and figures for all the measured data and charts of IR, MS, 1H-NMR for all the products. |