الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Summary
Synthesis and characterization of Some Ternary Complexes and their applications
Ternary complexes of metal (II) containing nitrogen and oxygen donor ligands had received considerable attention newly because they achieve high stability. In the other hand, ternary metal complexes had been recently studied due to their power as metal systems for metal protein complexes such as metalloenzymes. They had been received particular interest and had been used in cartographic protein surfaces, as feature for biological redox centers and in protein pick up for both purification and studying. In this study literature survey on the present work was carried out. And general introduction on ternary complexes and their importance, the amino acid, glycine (gly), as a primary ligand, and hydroxy acids i.e. salicylic acid (HL1), lactic acid (HL2) and glycolic acid (HL3), as a secondary ligand which were used during the complexes synthesis, their chemistry and usages.
Preparation of the Cu(II) and Zn(II) ternary complexes, the preparation of the 1:1:1 complexes of Cu(II) and Zn(II) with the amino acid, glycine (gly), as a primary ligand, and hydroxy acids i.e. salicylic acid (HL1), lactic acid (HL2) and glycolic acid (HL3), as a secondary ligand, prepared in a slightly acidic medium. It also includes the elemental analysis, physical and chemical
[Type text]properties of the prepared complexes and a detailed description of the instruments used in the research.
On reacting the Cu(II) and Zn(II) with the amino acid, glycine (gly), as a primary ligand, and hydroxy acids i.e. salicylic acid (HL1), lactic acid (HL2) and glycolic acid (HL3), as a secondary ligand, the complexes obtained have the following structure [Cu (L1)(Gly)], [Cu (L2)(Gly)], [Cu (L3)(Gly)], [Zn (L1)( Gly)], [Zn (L2)(Gly)], [Zn (L3)(Gly)]. The IR spectrum of ligands HL1, HL2 and HL3 showed bands at (1748 and 1300 cm-1), (1734 and 1130 cm-1), (1720 and 1230 cm-1) for free carboxylic groups, respectively. In the ternary complexes, these bands of carboxylic groups showed a respective shift towards lower frequency for asymmetric carboxylic group and respective shift towards higher frequency for symmetric carboxylic group. The difference between the symmetry and asymmetry stretching vibration for COO- group (Δυ= 177-206) gives an indication about the manner of coordination of the carboxylic group, this value shows that the hydroxy acids (HL1-3) coordinate through COO- group which acts as monodentate. The IR spectra of glycine showed bands at 3260 – 3100 cm-1 due to υN-H vibration. In ternary complexes, this band appeared as a broad band at 3155-3452 cm-1 due to coordination of metal with nitrogen and OH of ligands (HL1, HL2 and HL3) without losing its proton, since the solution of the ternary complexes is non-electrolytic.
[Type text]The ESR spectra for Cu (II) ternary complexes were recorded in polycrystalline solid at room temperature suggest square planer geometry.
The mass spectra of the six complexes were recorded. All the spectra contain molecular ion peaks confirm the molecular mass of the complexes.
Thermogravimetric analysis of the ternary complexes were carried out at temperature up to 700°C to ensure the proposed structure.
Biological study of these complexes was performed to show inhibitory effect to some bacteria species.
Application, Cu (II) and Zn (II) ternary complexes prepared were then incorporated into Solid lipid nanoparticles (SLN). SLN are the new generation of nanoparticulate active substance vehicles and are attracting major attention as novel colloidal drug carriers for topical use. Evaluation of Cu (II) and Zn (II) ternary complexes SLN using entrapment efficiency measurements, zeta potential, TEM, in vitro drug release, clinical study