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Abstract SUMMARY Acne vugaris is a common inflammatory pilosebaceous disease characterized by comedones, papules, pustules, inflamed nodules and superficial pus-filled cysts. Lesions are most common on the face, but the neck, chest, upper back, and shoulders may also be affected. Acne can cause scarring and considerable psychological distress . Acne occurs most commonly during adolescence, and often continues into adulthood. In adolescence, acne is usually caused by an increase in male sex hormones, which occurs in people of both genders during puberty. For most people, acne diminishes over time and tends to disappear ,or at the very least decrease ; after one reaches one’s early twenties. There is, however, no way to predict how long it will take to disappear entirely, and some individuals will carry this condition well into their thirties, forties, and beyond Zinc is an essential trace element which is necessary for plant and animal life, including microorganisms. It is the second most common abundant trace element in the human body and , in , such a member of one of the major subgroups of the micronutrients that have been attained such promince in human nutrition and health. Zinc makes up a part of more than 300 enzymes in the body. Important zinc containing metalloenzymes in human include carbonic anhydrase, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) polymerase, thymidine kinase, carboxypeptides . Zinc is the only metal encountered in each class,i.e. oxidoreductases, transferases, hydrolases, lyases, isomerases and ligases. Its physical and chemical properties make |