الفهرس 
Polycystic Ovary SyndromeOnly 14 pages are availabe for public view
 |  | from | 133 |  |  |
| | | from | 133 | | |
Abstract
Polycystic ovary syndrome (PCOS), traditionally thought of as a triad of oligomenorrhea, hirsutism, and obesity, is now recognized as a heterogeneous disorder that results in overproduction of androgens, primarily from the ovary, and is associated with IR. The disorder is characterized by oligo- or amenorrhea and signs of hyperandrogenism. Because many women who have PCOS have the onset of symptoms during adolescence, it is important to be able to recognize and understand this disorder so as to facilitate treatment and prevention of long-term sequelae.
Currently, CC is considered first-line therapy for ovulation induction for women with PCOS and infertility. It has variable efficacy (20–25% of women are CC resistant), discrepancies between ovulation and conception rates, and a long half-life (~5 days), which may result in negative endometrium and cervical mucus effects.
The present study was designed to compare the efficacy of combined CC with metformin versus CC only versus metformin PCOS.
This study was done on seventy-five documented case of PCOSthey divided into three groups each on contain 25case the first group receive metformin 500 mg three times daily for three monthes, the second group receive two tablets of CC 50mg from the 3rd day of the cycle for 5 days each cycle, the third group receive both regimens . These cases will were followed up for three cycles by transvaginal ultrasound folliculometry to document ovulation.
The results of the present study revealed that all lines of treatment were effective in treatment of PCOS patients, no statistically significant difference was found between CC group and metformin group as regard ovulation rate, number of follicles in the end of first, second or third cycles, or as regard the diameter of follicles, i.e., all regimens showed efficacy to the same extent.