الفهرس 
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Abstract
Pharmacokinetics of lincomycin was studied following single i.v and oral administrations (20 mg/kg b.wt) in both control and Gallimix (as acidifier) in medicated broiler chickens. Lincomycin serum concentration was determined by microbiological assay method. Following i.v. injection in group fed free acidifiers and acidifiers containing ration, lincomycin serum concentration versus time curve was best fitted a 2-comparment open model. It is clear that there is no significant differences in the values of distribution rate constant (α) and distribution half-life (t½α) of lincomycin Following Single oral administration of lincomycin in chickens fed acidifiers containing ration (1ppm) the calculated pharmacokinetic parameters indicated the peak concentration (Cmax) was 5.63±1.42 mg/ml and was achieved at Tmax (0.62±0.23) which is significantly lower (Cmax) and shorter Tmax than chickens fed on free acidifiers. The calculated bioavailability (F %) was 54.99±7.54% which is significantly lower than the corresponding one (80.13±4.68%) in chickens fed on acidifiers free ration.The average value of protein binding percentage of lincomycin to chicken’s serum proteins was 14.5±1.26%.Following residue studies the obtained results were revealed that lincomycin is found widely distributed in chickens fed acidifiers free ration. In conclusion: concomitant administration of lincomycin and Gallimix in broiler chickens must be not recommended as the interaction between them significantly reduces lincomycin blood concentration and tissue distribution which consequently decreases its therapeutic efficacy.