الفهرس 
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Abstract
Biomaterial-associated infections, most frequently caused by coagulase-negative staphylococci, are of increasing importance in modern medicine. Regularly, antimicrobial therapy fails without removal of the implanted device. The most important factor in the pathogenesis of biomaterial-associated staphylococcal infections is the formation of adherent, multilayered bacterial biofilms.
This work is aiming to the following objectives:
1- Isolation and identification of clinical isolates of Staphylococcus epidermidis.
2- Screening for the biofilm formation among the different clinical isolates of Staphylococcus epidermidis.
3- The susceptibility of clinical isolates of Staphylococcus epidermidis in free forms and in biofilm forms against different antimicrobial agents.
4- Inhibition of microbial adhesion and colonization of clinical isolates to the surfaces of some implanted devices.
5- Disaggregation (disintegration) of the biofilm matrix formed by some clinical isolates.
6- Molecular bases of biofilm formation in Staphylococcus