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Abstract INTRODUCTION Patients suffering from portal hypertension frequently bleed t’rom esophageal varices. This is a dramatic event accompanied by n high incidence of mortality which is about 50% after the first hemorrhage (Rigo eta! 1992). The factors that predispose to and prccipit lte v 1riccal hemorrhage have still not been clenrly identified (klacll111fluma eta/ 1992). !n normal individunls bleeding can result ti·om localized hyperfibrinolysis. Any ammmt or localized fibrinolysis could exaggerate local bleeding and favorably intluenced by fibrinolytic inhibitors (Prentice 1975). Certain lesions that cause upper or lower gastrointestinal bleeding have been associated with increased local fibrinolytic nclivity e.g. cirrhosis of the liver and bleeding due to esophageal V<lrices (0/(a and Tattttlur 1979). The mm of this work is to study the relationship between local fibrinolytic activity (i.e. in gastric juice) and bleeding tendency in cases of esophageal varices. This rel3tionship, if’ present, will be very useful in management and prophylaxis against bleeding episodes which are very dangerous. |