الفهرس 
Risk factors for HCCOnly 14 pages are availabe for public view
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Abstract
HCC is one of the commonest cancers worldwide. It is a major health problem and its incidence is increasing. The presence of cirrhosis is the major risk factor and this is largely due to chronic HCV and HBV infection. HCC carcinogenesis is likely to involve interplay of viral, environmental and host factors. Nevertheless, only a fraction of infected patients develop HCC during their lifetime suggesting that genetic factors might modulate HCC development. So the search for genetic factors that could help to select high-risk populations and thus to modulate the indications of screening procedures is necessary. Moreover, identification of predictive factors could lead to a better diagnosis and planning of new prevention strategies at risk individuals.
The RASSF1A Ala133Ser polymorphism might confer genetic susceptibility that influences hepatocellular carcinogenesis within the Egyptian population. It was an independent risk factor for HCC.
Statistical significant increase in p53 gene mutation among HCC patients compared to other groups denoting that p53 gene mutation may be the first step in hepatocarcinogenesis. It was a risk and prognostic factor for HCC.
Increase aflatoxins exposure among Egyptian populations. AAA was an independent risk factor for HCC.
Statistical significant increase in AAA in mutant p53 compared to wild type p53 denoting codon 249 of exon 7 of p53 gene is a hot spot point for mutation by AAA.
VEGF statistically significant increase in HCC group compared to other groups. It is a marker for angiogenesis and vascular invasion so it is a prognostic factor in HCC.
Serum ferritin was statistically significant increased in HCC compared to other groups.
Nutritional status and hypovitaminosis such as vitamin B12 deficiency may be risk factor for HCC and other CLD.
Interestingly in this study after doing multivariate logistic regression analysis revealed that among those all risk and prognostic factors only RASSF1A Ala133Ser gene polymorphism and AAA are the most risk and predictor factors for HCC.
AFP stills the best screening and prognostic test for HCC.