الفهرس 
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Abstract
4,5 ,6,7-Tetrabromo-2-[4-(4-chloro-benzylidene)-5-oxo-4,5-djhydrooxazol..
2-ylmethyl]-isoindole-1,3..djone (1) was obtained from the condensation of
aromatic aldehydes with aroylglycine, via Erlenmeyer synthesis.
It reacts with primary amines namely, (propyl amine, pentyl amine, hexyl
amine, p-nitroaniline, p-anizidene, p-phenylene-diamine) in DMF solution to
give the corresponding 3 -(4-Chloro-phenyl)-N-alkyl-2- [2-(4,5 ,6,7-tetrabromo-
1 ,3-dioxo- 1 ,3,3a,7a-tetrahydro-isoindol-2-ylacetylamjno]acryl amide (2a-f)
The oxazolone (1) reacts with secondary amines namely, piperidine to yield
N-[2-(4-Chloro-phenyl)- 1 -(piperidine- 1 -carbonyl)-vinyl]-2-(4,5 ,6,7-tetrabromo-
1 ,3-dioxo- 1,3 ,3a,7a-tetrahydro-isoindol-2-y~-acetamide (3).
Compound (1) reacts with amino acids in DMF to give the corresponding
3-(4-Chloro-phenyl)-2-[2-(4,5,6,7-tetrabromo- 1 ,3-dioxo- 1,3,3 a,7a-tetrahydroisoindol-
2-yl)-acetyl-amino]-acryloylamino}acetjc acid (4,5).
It reacts with hydrazine hydrate in DMF solution to give the corresponding
N-[2-(4-Chloro-phenyl)- I -hydrazinocarbonyl-vinyl]-2-(4,5 ,6,7-tetrabromo- 1,3 -
dioxo- 1,3,3 a,7a-tetrahydro-isoindol-2-yl)-acetamide (6). Similarly, it condensed
with phenyl hydrazine in boiling DMF and yielded the corresponding N-[2-(4-
Chloro-phenyl)- 1 -(N-phenyl-hydrazino-carbonyl)-vinyl]-2-(4, 5 ,6,7-tetrabromo-
1 ,3-dioxo-1 ,3,3a,7a-tetrahydro-isoindol-2-yl)-acetamide (7).