الفهرس | Only 14 pages are availabe for public view |
Abstract Parathyroid hormone is a middle sized molecule with a molecular weight of 9500 Da. Hyperparathyroidism is a common finding in patients with renal insufficiency. Calcitriol deficiency and phosphate retention together with hypocalcaemia are main factors involved in pathogenesis of secondary hyperparathyroidism. Excess parathyroid hormone causes a rise in intracellular calcium, disturbing the functions of virtually every organ system, including bone mineralization, pancreatic response to metabolic and hormonal changes, erythropoiesis, the immune system, the heart, the liver, or the brain. The aim of the study is to assess the effect of high-flux versus lowflux dialysis membranes on parathyroid hormone in chronic hemodialysis patients. The current study comprised 40 adult hemodialysis patients. These patients were enrolled from Hemodialysis Unit,Benha Teatching Hospital after fulfilling of our inclusion criteria. These patients were subjected to full history taking and clinical examination. Laboratory evaluation was undertaken including: - Routine investigations including CBC, serum calcium level, phosphorus level, Serum creatinin , blood urea nitrogen, and albumin were measured at the beginning of and 1 month after the use of high flux dialyzer. 2 - Quantitation of intact parathyroid hormone was measured by Enzyme Linked Immunosorbant assay (ELISA) before hemodialysis session and 30 minutes after HD session. Intact PTH was remeasured before and 30 minutes after the hemodialysis session after 1 month of use of high flux dialyzer. In our study we found postdialysis highly significant decline of intact PTH after the use of high flux membranes,but not after the use of low flux ones. Also predialysis intact PTH level after the use of high flux membranes showed a highly significant decline compared to the predialysis intact PTH with low flux membranes at the start of the study. |