الفهرس 
Acute Lung InjuryOnly 14 pages are availabe for public view
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Abstract
Acute lung injury was first described in 1967, and is characterized by the abrupt onset of clinically significant hypoxaemia with presence of diffuse pulmonary infiltrates. These infiltrates show on radiograph as pulmonary oedema resulting from increased pulmonary vascular permeability.This disorder affects patients of all ages and usually happens soon after an easily identified triggering event. Adhesion molecules appear to play a central role in tissue damage secondary to inflammatory response. Soluble forms of endothelial-derived adhesion molecules including sICAM-1 have been detected in the circulating blood in recent years. They seem to be good markers of endothelial damage, but their importance in the critically ill has not been definitely elucidated yet. The objective of the study was to demonstrate that elevations in sICAM-1 as a marker of lung epithelial and endothelial injury, are associated with poor clinical outcomes including mortality and long need for ventilatory support in PICU patients with ALI and hence we can predict the outcome using this marker.