الفهرس 
Anticholinesterase pesticide poisoningOnly 14 pages are availabe for public view
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Abstract
Anticholinesterase pesticides are widely used in agriculture and domestic settings throughout the world. It is responsible for great morbidity and mortality especially in developing countries as Egypt.Anticholinesterase pesticides exposure may cause acute and chronic adverse health effects. Acute Anticholinesterase pesticides poisoning exert toxicity via a common mechanism of action, binding to and phosphorylation of the enzyme acetylcholinesterase resulting in overstimulation at muscarinic and nicotinic cholinergic synapses by acetylcholine.Diagnosis of anticholinesterase pesticide poisoning is based on clinical suspicion, characteristic clinical signs, smell of pesticides or solvents, and reduced butyrylcholinesterase or acetylcholinesterase activity in the blood.The traditional antidotes of anticholinesterase pesticide poisoning are atropine and oximes, such as pralidoxime and obidoxime. The use of atropine must be meticulously done to prevent overdosing. Therefore, new drugs supplementary to or partly substituting for atropine are urgently needed.