الفهرس 
aluminium oxide.Only 14 pages are availabe for public view
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Abstract
The aim of this work is to study the genotoxicity of aluminum oxide on the chromosomes of the adult male albino rats. Material & methods : Twenty adult male albino rats were used in this study, their average weight is 100-120 grams, and they will be divided into two groups: 3- Control group: this group was consisted of 10 rats, they were subdivided into two subgroups: a- Subgroup I-A (-ve control): this group was consisted of 5 rats, they were kept without any treatment and serve as control for all experimental groups. Rats were sacrified after 24h. b- Subgroup I-B (+ve control): this group was consisted of 5 rats, they will receive 0.5 ml of 1% Tween 80 in double distilled water (DDW), the solvent used to dissolve aluminium oxide. 4- Aluminium oxide treated group: this group was consisted of 10 rats, they were received 500 mg/kg bw. aluminium oxide orally by using syring immediately in the mouth of rats. Rats were sacrified after 24h. The bone marrow were extracted from the femur and searched for chromosomal abberrations.
Results : Group I (control group): On studying the chromosomal analysis of both –ve and +ve control aimals, there are normal chromosomal number and structure. each wellspread metaphase was consisted of 50 chromosomes. All of which were normal telocentric, metacentric, submetacentric or acrocentric in appearance. By using paired t-test to compare between subgroup I-A (+ve control group) and subgroup I-B (-ve control group), there was no significant difference (P>0.05) considered for both aberration percentage and mitotic index. Group II (treated group): On studying the chromosomal analysis of Al.O treated group that were received a 500mg Al.O, there were different types of aberration were detected. These aberrations were in the form of chromatid, Fragmentation, Centromeric attenuation, end to end association, Centric fusion, break, gap, chromosomal ring and stickness. Meanwhile no numerical aberrations were found in all animals. By using paired t-test to compare Al.O treated group with control group, it was observed that there were increased in the percentage of the total chromosomal aberrations as follow: There was a very high significant increase in chromatid deletions in treated group comparing to control group in which deletions were non-significant (table 1)