الفهرس 
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Abstract
Genital HPV is the most common sexually transmitted infection among young adult women (Arbyn et al., 2009).
Lesions induced by HPV are usually associated with vaginal infection (Fang et al., 2007).
Biologic susceptibility to HPV acquisition and immune competence for clearance of an HPV infection could be affected by common, treatable vaginal infections that disrupt the balanced vaginal ecosystem and its innate protective mechanisms against infection and disease (Schiffman and Castle, 2003).
Chronic cervical inflammation seems to influence the HPV persistence through the reduction in host cell-mediated immunity, for the vulvovaginitis the women with Candida and BV infection was associated with a lower rate of HPV clearance (Verteramo et al., 2009).Also TV infection is particularly associated with HPV by increasing their infectiousness (Van Der Pol, 2007).This study included 120 women in the childbearing period attending early cancer detection unit at Ain Shams University.The aim was to assess the prevalence of vulvovaginitis in women with and without HPV infection.
With the patient in modified lithotomy position the cervix was exposed with Cusco speculum, cervicovaginal smears were taken using Ayres spatula, and spread immediately on clear glass slide.All smears collected were sent to the Microbiology Laboratory of Ain Shams University Maternity Hospital.
The diagnosis of HPV infection depended on the presence of koilocytosis in Pap smear and it was an information used to divide the patients into two groups.
•The positive group: Pap smear with the presence of koilocytosis. •The negative group: Pap smear with absence of koilocytosis.
For the diagnosis of vulvovaginitis it dependant on:• VVC: presence of Candida hyphae in Pap test.
• BV: by higher proportion of clue cells and vaginal Ph above 4.5.• TV: as many pear- shaped tricomonads are shown in Pap smear. from the study we found that:•The prevalence of vulvovaginitis in women with HPV was 93.3% (Candida was 58.3%, followed by 18.3% BV andTVwas16.7%).•Prevalence of vulvovaginitis in women without HPV was 46.73% (Candida was 30.1%, followed by 13.3% BV and TV was 3.3%).•The overall prevalence of vulvovaginitis in all women under the study was 44.2% for Candida, 15.8% for BV and 10% for TV. • Early age of first intercourse is a significant risk for HPV infection.• Multiple sexual partners related to HPV infection with high significance. •High parity is highly significantly related to HPV infection.