الفهرس 
ACUTE CORONARY SYNDROMESOnly 14 pages are availabe for public view
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Abstract
A
cute coronary syndromes are currently one of the leading causes of death in industrialized countries & are expected to become so in emerging countries by 2020.
Management of patients presented with ST elevation myocardial infarction is rapid reperfusion either by primary PCI or firinolysis while patients presented with non ST acute coronary syndromes varies according to the risk stratification of the patients from conservative management, early invasive & very early invasive strategy
The aim of the study is to assess the use of heart-type fatty acid binding protein (H-FABP) as an early diagnostic biochemical marker of myocardial ischemia in patients with acute coronary syndrome and compare it with troponin and creatine kinase-myocardial band as regard sensitivity, specificity and time of early detection. This is for proper and optimal management.
The study included 100 patients who presented by chest pain within the first 6 hours from its onset, they were admitted to the CCU as cases of suspected acute coronary syndromes & involved in a diagnostic prospective study.
The population in the study underwent detailed history taking, clinical examination and serial ECG monitoring. Echocardiography was done to all patients.
All patients had normal kidney functions tests. Blood samples for H-FABP, Troponin and CK-MB were obtained on admission for patients presenting to ED within the first 6 hours of onset of chest pain.
Patients were subsequently monitored by serial measurement of Troponin and CK-MB for myocardial necrosis.
Sensitivity and specificity of cardiac markers were calculated in detection of myocardial ischemia and necrosis to all population included in the study.
Our study showed sensitivity of 89.7%, 47.4% and 53.8 % for FABP, CK-MB and Troponin respectively. It showed also specificity of 95.5%, 81.8% and 100 % for FABP, CK-MB and Troponin respectively.