الفهرس 
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Abstract
it is now more than 150 years since flr Hodgkin first described the curious disease of the lymphoid system that was later to bear his name . The knowledge about Hodgkin’s disease (11.0) has been much expanded during the last 25 years (Kaplan , 1 980 aL
immunoglobulin serum levels in HO. were studied by many investigators , and there was marked discrepancy in their results Hancock ci at (1976) found no change in their values from that of the controls , while others showed increase in their levels in 11.0. patients (Walter ci at, 1980 - Van Rijswi]k ci at, 19811. However Iyer ci at (1982)detected increase in IgG and 1gM and decrease in IgA in H.D. patients when compared to controls.
The choice of treatment for patients with H.D. has to be made after precise knowledge about the extent of the disease. Changes in the stage from those found at the clinical examination have frequently been reported after staging laparotomy and demonstrated that one cannot assign the clinical stage of involvement with complete accuracy by preoperative examination and investigations only (Afariln ci at, 1982 - Taylor ci at
19852 However the operation of splenectomy may be followed by some severe complications e.g. septicemia which may be fatal especially in children , this is because of the deficiency in immunity produced by removal of the spleen . So the benefits of early accurate staging with laparotomy must be weighed against the likelihood of infective complications (Iliacock et a!., 19761
In this work serum irnmunoglobulin levels will be studied in patients with I-LD. as well as the changes in their values after splenectomy , in a trial to evaluate the effect of splenectomy on humoral immunity.