الفهرس | Only 14 pages are availabe for public view |
Abstract Stomach ulcer still a medical problem that face several patients in a wide range of age of both sexes worldwide. Long term uses of nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin are the second most common cause of ulcers after H. pylori. Enormous drugs are available for the treatment of gastric ulcers, but these drugs proclaim serious side effects.Therefore the aim of this study was to evaluate the antiulcerative effects of the water extracts of four plant herbs individually and in a mixture toward Aspirin namely; chamomile (Matricaria chamomilla), turmeric (Curcuma longa), ginger (Zingiber officinale Rosc.) and licorice (Glycyrrhiza glabra). Sixty five malealbino wistar rats were divided into 13 groups, two different concentration 200 and 400 mg/kg bodyweight of herb extracts or their mixture against 400 mg/kg Aspirin were used. Additionally, Omeprazole 20 mg/kg was used as standard antiulcer drug. Gastric juice volume, acidity, pH value, ulcer index, histological changes, complete blood picture, serum GOT and GPT, counts of total viable bacteriaand molds were measured to determine the antiulcerative effects of these herbs. Results obtained showed that: The effect of aspirin and plant herbs on rat’s body and organs weight. No significant changes in the body weights were observed in control positive (aspirin) as compared to control negative group. Similar observation was also noticed in Omeprazole, turmeric 200 mg, ginger 200 mg, mixture 200 mg as well as both concentration of licorice.On the other hand all other herbextracts including turmeric 400 mg, ginger 400 mg, mixture 400 mg and both concentrations of chamomile showed significant increasein weight gain compared with control positive (P ≤0.05). 93 There was significant increase in stomach weight in control positive group compared with control negative (P ≤0.05). Similar observation was also archived by Omeprazole and chamomile 400 mg. Whereby, all other extracts showed significant attenuation and reduction in stomach weight to the levels of control negative (P ≤ 0.05). It was observed that there was no significant deference in relative weight of liver between control positive and negative groups. Where, Omeprazole and both concentrations of licorice exert significant reduction compared to control positive (P ≤0.05). No significant deference on kidney weight between control positive and negative. On the other hand Omeprazole and all other herb extracts at both concentrationsexhibited significant reduction on kidney weight (P ≤0.05). No significant deference concerning spleen weight, neither between control positive and negative nor between all other treatments. It was noticed that there was significant increase (P ≤0.05) in heart weight of control positive compared to control negative group. Moreover all herbs extracts as well as Omeprazole showed significant decrease (P ≤0.05) compared to control positive. Significant increase (P ≤0.05) in lungs weight of control positive compared to control negative group was observed. In addition Omeprazole, ginger 400 mg and licorice 400 mg exert significant reduction compared to control positive (P ≤0.05). The effects of herb extracts on Aspirin induced gastric ulcer Effect of aspirin onulcer induction Results showed that, single dose of Aspirin (400mg/kg) for two consequence days was able to induce sever ulcer on stomach of 5.50±0.25 mm length. |