الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
from these results we can conclude that tissue ACE levels are higher in
psoriatic patients when compared to healthy control subjects, this high
tissue ACE level is most evident in psoriatic lesions but also present &
significant in non psoriatic skin of the patients when compared to
controls., this supports the theories of the importance of ACE in the
pathogensis of psoriasis. ACE gene polymorphism affects tissue levels of
ACE in psoriatic patients, leading to higher levels of ACE in psoriatic
skin in patients showing DD polymorphism followed by those of ID
followed by II polymorphism & this difference is also present in the
healthy skin of the patients but to a lesser extent. Tissue ACE levels in
psoriatic patients whether in psoriatic lesions or non affected skin, are not
related to age or sex of the patients, or affected by the extent, PASI score
or duration of psoriasis in the patients. We can also assume that in the
Egyptian population there is no prevalence of a certain ACE gene
polymorphism type in psoriatic patients. And that the ACE gene
polymorphism in psoriatic patients does not affect the age or sex
distribution, the age of onset of psoriasis, clinical type, extent, or even
PASI score among the patents. It’s also not related to associated
hypertension or family history of psoriasis. Further studies on a larger
scale are needed to investigate the ACE gene polymorphism distribution
among psoriatic patients as well as other cutaneous disorders. Studying
the effect ACE gene polymorphism in psoriatic patients upon the
cardiovascular events and metabolic syndrome is also recommended.