الفهرس | Only 14 pages are availabe for public view |
Abstract The present study deals with the synthesis of some new phenolic and indolic compounds incorporating pyrazole moiety, starting from 4-arylidene-3-methyl-1-phenyl-5-pyrazolones as key starting compounds. The material presented in this thesis is separated into two main parts. Part I: Includes the reaction of 4- arylidenes (2a-c) with polyhydric phenols under different conditions. Mannich reaction with the 4-arylidenes to give phenolic bases. Part II: The synthesis of some new indolic compound by treating (2a-c) with indole derivatives and antipyrine or pyrazolone derivatives. • The chemical structures of the new compounds were supported by analytical &spectral data • The newly synthesized compounds were screened for their antioxidant activity; have an ability to protect DNA from the induced damage by bleomycin and have ability for transformation (proliferated) blasts. |