الفهرس 
Autism spectrum disordersOnly 14 pages are availabe for public view
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Abstract
The autism spectrum disorders (ASD) or the pervasive
developmental disorders (PDD) are two synonyms of the same group of
disorders. They comprise a group of neuropsychiatric disorders
characterized by specific delays and deviation in social, communicative,
and cognitive development, with an onset starting before 3 years. despite
the great array of observations being made at the cellular and molecular
dysfunctions associated with autism spectrum disorders, the basic central
mechanism of these disorders hasn‘t been proposed in major scientific
literature. Multiple etiological factors were discussed including genetic,
biochemical, immunological, perinatal, neuroanatomical and
psychosocial factors .
Glutamate is the principal excitatory neurotransmitters in the
mammalian brain. The brain contains abundant glutamate receptors and
that destruction of different brain structures could result from excessive
stimulation of these receptors leading to many neurodevelopmental or
neurodegenerative disorders through a process known by
immunoexcitotoxicity. In autism spectrum disorders,
immunoexcitotoxicity is accused to be the cause behind the
neurodevelopmental changes that occur in autistic patients .
Key Words :
Antigen presenting cells - Dimethyl glycine – Methylphenidate .