الفهرس 
COVEROnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
The current work was done in order to study the crucial role of Natural Killer cells and Natural Killer T cells in pathogenesis of HCV infection comparing to healthy control.
The present study was conducted on 30 non-diabetic adult patients with chronic HCV infection, who were recruited from the Internal Medicine and Hepatology outpatient clinics at Ain Shams University Hospital. They included 18 males and 12 females. The age of the patients ranged from 27 to 52 years. All patients had been previously diagnosed with chronic hepatitis due to HCV infection, and were seropositive for HCV antibodies, and positive for HCV-RNA by PCR. Chronic hepatitis was diagnosed by the presence of elevated ALT levels for at least the past 6 months, in addition to liver biopsy, which was performed for all patients as part of their routine workup at the clinic.
For all included cases full medical history was taken, clinical examination was done together with (liver functions, kidney functions, Hb%, and fasting blood sugar and 2 hour post prandil and Triglycerides).
The result of the present study showed that there is a decrease in NK cells & NK T cells in HCV patient (CD3-& CD56+) NK and (CD3+&CD56+) NKT and subsets in peripheral blood Compared to healthy control,