الفهرس 
Chapter IOnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
Recurrent spontaneous abortion is defined as 2 or more consecutive pregnancy losses in the first trimester of pregnancy. The present study aimed to investigate the relationship between recurrent pregnancy loss and single nucleotide polymorphisms in protein Z (PZ) intron F G79A gene and the promoter region of the interleukin (IL)-6 C634G gene in Egyptian females. This study included 70 participants; 40 patients were suffering from early recurrent miscarriage, their age ranged between 18-38 years with a mean value of 27.95 5.9 & 30 unrelated apparently healthy & parous volunteers as controls, their age ranged between 19-32 years with a mean value of 26.3 4.87. The results of this study showed as regards PZ F G79A polymorphism; a higher prevalence of the A allele (GA & AA genotypes) in controls (53.3%) compared to cases (22.5%) & the difference proved to be statistically significant (P = 0.008, OR = 0.254, 95%CI = 0.090 – 0.713). As for IL6 C634G polymorphism; the frequency of the G allele (CG & GG genotypes) was higher in controls (100%) than in cases (95%), but the difference did not prove to be statistically significant (P = 0.503, OR value = 1.392, 95%CI = 0.517 – 3.752). A comparison between the prevalence of PZ intron F G79A & IL6 C634G polymorphisms among patients showed that the frequency of the C634G gene polymorphism (95%) was higher than the frequency of the G79A gene polymorphism (22.5%). The difference proved to be statistically significant (P = < 0.001). These results suggest a protective role for the PZ intron F G79A polymorphism against RPL, but IL6 C634G polymorphism did not prove to have a protective effect against RPL. Key words: Pregnancy, miscarriage, recurrent pregnancy loss, protein Z, Protein Z intron F G79A polymorphism, IL-6, IL-6 C634G polymorphism