الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
To clarify a possible role for ANP in the pathophysiology of pregnancy complicated by hypertension we studied plasma
They were classified into 4 groups: 1) Group I. normal nonnpregnant women ~ = 10). 2) Group II. healthy pregnant women during the third trimester (n = 20). 3) Group III. 30 preeeclamptic pregnant women (IIIa)20 with severe pre-eclampsia
and (IIIb)lO with mild disease. 4) Group IV. (n = 12) preegnant women during third trimester and their pregnancies were
All pregnant women were matched for age and gestational period. Plasma ANP, PRA, serum aldosterone, serum Na anc K were measured i the four groups studied.
compared to either group I or II. The difference between the two hypertensive groups was insignificant. Plasma ANP concentraations increased significantly with severity of pre-eclamptic
Serum a1dost rone and PRA were significantly reduced in severe pre-eclamptic and chronic hypertensive groups compared to normal pregnant women while the reduction was insignificant in mild pre-eclamptic group on the other hand their levels
were significantly increased in healthy pregnant women compared to non pregnant women.
Serum Na ~as significantly reduced in severe pre-eclamptic and chronic hypertensive groups while serum K levels did not show a significant alteration between the four studied groups.
An inverse relationship betwe n plasma A.’P, and either serum aldosterone, Ja and FRA was found in the se ’ere preeeclamptic and the chronic hypertensive groups while insignificcant correlation ~as found in the mild pre-eclamptic group.
Our results confirm that plasma A 1p levels are increased during third trimester of normal pregnancy and increased more in pregnancies complicated by pre-eclampsia and chronic h;perrtension. The latter may reflect a mechanism of compensation that operates in response to water and sodium r tention. ~vere pre-eclampsia and chronic hypertension were also assoociated with decreased serum aldosterone, sodium and plasma renin activity.