الفهرس | Only 14 pages are availabe for public view |
Abstract Effect of Neem (Azadirachta indica) Extract on Some Tissues and Biochemical Parameters in Rats Treated with Cisplatin Cisplatin, an effective antineoplastic agent, IS toxic to the liver and kidney. Since, this study was aimed to investigate the protective effect of methanolic neem (;1zadirachta indica) leaves extract against cisplatin-induced hepato- and nephrotoxicity. Methanolic neem leaves extract (MNLE) showed significant protection as evidenced by the decrease of elevated serum alanine aminotransferase,aspartate aminotransferase, gamma glutamy I transferase, alkaline phosphatase, total bilirubin, creatinine, uric acid and urea pre-, post- and co-treatment of neem. This improvement of physiological function was associated with highly refinement of histological and histochemical effects of carbohydrates and total proteins III liver and kidney. These findings suggested that MNLE pre-, post- and co-treatment can prevent the hepato- and nephrotoxicity induced by cisplatin. Keywords: Azadirachta indica; CispJatin; Liver; Kidney; Rats. |