الفهرس | Only 14 pages are availabe for public view |
Abstract The present work was aimed at the development of bioactive polymeric materials J_g characteristics potentially useful in drug delivery systems. As already well a careful design of polymeric structures can produce highly tailored properties :inal material and suitable biodegradation rates. Encapsulation and release of e agents can be finely tuned by modifying with the chemical composition and the :ilic/hyDROPhobic balance of the polymeric materials. F Dly(-caprolactone) (PCL) and methoxy poly(ethylene glycol) (mPEG) chosen range of molecular weights and compositions, were the building blocks of the meric materials investigated in this work. Both of them are already well-established -z of physico-chernical properties and biocompatibility. By choosing suitable :: pathways, these polymeric materials were prepared to be used for drug delivery The synthesis of three series of AB-type amphiphilic diblock copolymers, -rg PCL and mPEG segments, was also investigated. A synthetic strategy was ented by using stannous octoate catalyzed ring-opening polymerization of - atone monomer initiated by iriPEG macroinitiator. Different feed ratios of the - ronomer to initiator were expected to yield polymeric materials with different :eristics in terms of chemical composition, hyDROPhilic/hyDROPhobic balance, etc. - - erization by Fourier Transform Infra-Red (FT-IR), Proton Nuclear Magnetic rice (‘H-NMR), Gel Permission Chromatography (GPC), Differential Scanning -- retry (DSC) and Wide Angle X-Ray Diffraction (WAXD) of the polymeric : is expected to provide information about the composition, structure and - eristics of the final polymeric materials. \noparticles were prepared by the emulsification-solvent evaporation method on the formation of double (water/oil/water) emulsion from the prepared -mer. Nanoparticles were characterized in terms of morphology and size. In nanoparticles containing methylene blue as a photosensitizer were prepared by emulsification method based on the formation of double (water/oil/water) ::n. Their morphology and size were characterized using transmission electron opy (TEM) and particle size analysis (PSA |