الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
The present study was done due to increased incidence of cocaine and amphetamine abuse not only among young adults but also among pregnant women and to detect the possibility that chronic cocaine and amphetamine exposure can cause histopathological changes in the cochlea of the adult and neontal group.
The study was done in forensic and toxicology department, faculty of medicine, EI-Minia University.
60 gumea pIgS were used and divided into 3 groups (cocaine, amphetamine and control group) and in every group each male and female guinea pig were isolated in separate cage.
The lIrst group was given chronic dose of cocaine for 3 moilths and the 2nd group was given chronic dose of amphetamine and the third group normal saline . After this, dissection of the cochlea was done for the adult and neonate for every group .
After preparation for histopathological examination light microscopic examination was done.
Results of this study light microscopic examination revealed that chronic cocaine exposure can cause oedema of the striavascularis and degeneration of spiral ganglionic cells in the cochlea of the adult group, However in the cochlea of neonatal group of guinea pig can cause necrosis, degeneration and loss of
spiral ganglionic cells, loss of external and internal hair cells aoutolysis of auditory nerve, collapse and vacular degeneration of organ of Corti.
In the 2nd group chronic amphetamine exposure can cause collapse of organ of Corti, degeneration with focal necrosis of spiral ganglionic cells and swelling of the tectorial membrane in the cochlea of the aduTt group, however in the cochlea of neonatal group of guinea pig can cause vacular degeneration of organ of Corti and degeneration of the spiral ganglionic cells.
Light Illlcroscope examination of the cochlea of the control group revealed no abnonnal histopathological changes.