الفهرس 
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Abstract
Celiac disease (CD) is a permanent intolerance to specific proteins found in some cereals (wheat, rye, barley) occurring in genetically susceptible subjects and triggered by immune-mediated mechanism of the small intestine .
CD caused inflammation involves the mucosa alone, and the infiltration of lymphocytes, eosinophils, and plasma cells causes a deep alteration of mucosal architecture characterized by progressive involution of villi and hyperplasia of crypts, with eventual progression to total atrophy of mucosa. The worsening changes of mucosal anatomy cause malabsorption, lead to abdominal pain, bloating, and diarrhea.
Children tend to have the more classic signs of celiac disease, including growth problems (failure to thrive, chronic diarrhea/constipation, recurring abdominal bloating and pain, fatigue and irritability).
Adult tend to have symptoms that are not entirely gastrointestinal in nature. Only a third of adult patients diagnosed with celiac disease have experience diarrhea. Weight loss is also not a common sign but iron deficiency anemia is more frequent..
Complications of CD range from malabsorption to cerebellar ataxia, dilated cardiomyopathy, infertility, malignancies (oropharyngeal, gastrointestinal and thyroid malignancies) , lymphoma, as well as Metabolic bone disease, and autoimmune conditions may develop if treatment is delayed.