الفهرس 
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Abstract
The aim of this study was to detect the prevalence of PHT and
cardiac involvement among TI patients, its relationto various clinical and
laboratory characteristics of those patients and the possible effects of
different therapeutic strategies used in managementof TI patients on the
development of PHT.
This study was conducted in the Pediatric Hematology Clinic,
New Children’s hospital, Cairo University. It included sixty patients with
thalassemia intermedia (45 child and 15 adult). Allpatients were
subjected to full history and through clinical examination with stress on:
age at diagnosis, frequency of blood transfusion, splenectomy,
cardiovascular symptoms and chelation therapy, the size of liver and
spleen.
Complete blood picture, differential leucocytic count,
reticulocytic count, serum ferritin and lactate dehydrogenase (LDH),
alanine transaminase (ALT), aspartate transaminase (AST) and serum
bilirubin (total, direct), coagulation profile and Hb electrophoresis were
done for all patients at the time of enrollement. Echocardiography
examination was performed at Echocardiography Laboratory of Abu El-Reesh Hospital, Faculty of Medicine, Cairo University. Trans-thoracic
two dimensional (2D) guided (M mode) and Doppler echocardiogram
was performed for all patients.