الفهرس 
Platelet ?-granule constituentsOnly 14 pages are availabe for public view
 |  | from | 147 |  |  |
| | | from | 147 | | |
Abstract
Platelet play a complex role in hemostasis and thrombosis. The expression of multiple membrane receptors, both constitutive and activation dependent, mediates platelet adhesion and aggregation at sites of vascular lesion. Platelets normally circulate in quiescent state, their activation leads to exocytosis of granular constituents, release of newly synthesized mediators, change their shape as well as the expression pattern of adhesive molecules.
Platelets has a critical importance in cardiovascular disease (eg; IHD, stroke and PAD) throw its ability to activate and aggregate to form blood clots in response to endothelial injury and plaque rupture. Therefore platelets are important contributors to ischemia in atherothrombosis. platelets are also important mediators of inflammation and play a central role in atherogenesis itself.
Patients with CHD show a significant bleeding tendency and that’s may be due to hemostatic defects, including thrombocytopenia, shortened platelet life-time, suppressed platelet aggregation and deficiency of clotting factors. They may also be considered susceptible to an increased risk of stroke and thromboembolism. Endothelial dysfunction, hemostatic abnormalities and platelet activation may be underlying factors causing hypercoagulability and thromboembolism.
Heart failure is associated with increased risk of venous thromboembolism, stroke, and sudden death. These thrombosis-related complications in patients with HF have been attributed to many platelet abnormalities.
Pathogenesis of vascular inflammation and thrombosis involves many informatory mediators which is mostly derived from platelets. Platelet activation occurs in peripheral blood of patients with rheumatic heart disease.
Managing antiplatelet therapy for patients with cardiovascular diseases is complex, and current therapy options and approaches for these patients are still suboptimal
So as Platelets play a key role in both hemostasis and thrombosis. Accordingly, not only is accurate measurement of platelet function critical for identifying patients with platelet dysfunction or hyperfunction but it also is becoming increasingly important for the monitoring of modern antiplatelet therapy.
In conclusion, knowledge regarding the important role of platelets in cardiovascular disease both in the pathogenesis of atherosclerosis and in the development of acute thrombotic events, and the associated role and benefits of anti-platelet therapies.