الفهرس 
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Abstract
The present study was designed to evaluate the effect of early administration of hypertonic saline on adequacy of resuscitation, progression of inflammation and outcome of critically ill septic patients according to occurrence of septic shock, need for mechanical ventilation, ICU length stay, and ICU mortality.
Our study consisted of randomized thirty Egyptian patients divided into two groups: The study group consisted of fifteen adult patients with sepsis received 4ml/kg 7.5% hypertonic saline over 15 minutes plus standard medical therapy, compared to the control group which consisted of fifteen adult patients with sepsis received standard medical therapy alone. All patients aged between 30 and 50 years, without end organ dysfunction(altered organ function such that normal physiology cannot be maintained without support), without persistent hypotension, without circulatory support or mechanical ventilation, and without pre existing severe organ system dysfunction.
All included septic patients were subjected to the measurements of hemodynamic parameters including (MABP, HR, U.O.P, C.V.P) at the start of the study (base line), and then every 2 hours for 48 hours, measurements of respiratory parameters including (RR, ABG, internal jugular venous oxygen saturation) at the start, then every 24 hours for 48 hours, measurements of laboratory parameters including (CRP, WBC count, TNF-α) before resuscitation and after 48 hours. All patients were followed up for a total of 30 days from the date of ICU admission.
The result of the study showed that HTS 7.5% has prophylactic role in progression of inflammation in septic patients as HTS 7.5% 4ml/kg infusion lead to significant reduction in laboratory parameters of inflammation (CRP, WBCs and TNFα) by significant p values(0.034, 0.019 and 0.001) respectively with significant improvement of tachycardia and tachypnea induced by sepsis by significant p values(0.049 and 0.001)and reduction of occurrence of metabolic acidosis by p value 0.019, so HTS infusion lead to improvement of outcome of critically ill septic patient according to occurrence of septic shock, need for mechanical ventilation, ICU mortality and the mean ICU length of stay with significant p values(0.006, 0.006, 0.032 and 0.001 respectively).