الفهرس 
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Abstract
Objective: To determine the predictive value of serial study of gastric mucosal changes in critically ill patients and also that of early determination of plasma ET-I levels.
Design: Prospective, observational cohort study.
Setting: ICU in Mansoura University Hospital.
Patients: Thirty critically ill patients were admitted to ICU with different diagnoses.
Interventions: Upper gastrointestinal endoscopy in the day of admission and after bleeding in all patients.
Measurements and Main Results: Plasma endothelin-1 levels starting from the day of admission in addition to the general hematologic and biochemical profiles were measured. APACHE II and MOD scores were measured daily as clues for outcome. The results of these measurements indicated that SRMD significantly can affect APACHE II and MOD scores (P <0.05) starting from the 5 day of the study, and that there was no significant effect of SRMID in relation to survival, but on the contrary bleeding significantly affected survival. On the other side there was a significant effect of increasing levels of plasma ET 1 on survival.
Conclusion: Both SRMD and plasma ET-l are good predictors of outcome in critically ill’ patients.