الفهرس 
HISTORY OF STEM CELL AND BIOLOGICAL BACKGROUNDOnly 14 pages are availabe for public view
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Abstract
Heart failure is the end stage of all diseases of the heart and is a
major cause of morbidity and mortality .Congestive heart failure is the
common final pathway for Patients with ischemic & non Ischemic
cardiomyopathies. Therapeutic options mainly target on the consequences
of heart failure, like this overlaps: & neuro hormonal activation which are
Known to be long-term deleterious. However, improvements of
ventricular contractility by restoration of cardiomyocyte contractile
capacity has not been an issue until recently The organism is made up of
two kinds elements; first, the adult cell that cannot revert to the
embryonic state & unable to develop regenerative activity; second, the
germinal corpuscles, which are undifferentiated cells that are specific to
each tissue. These second cells are devoid of useful physiological activity
but they do control tissue regeneration, both during normal physiology
and in pathological processes.
Contrary to the general belief, the restricted regenerative capacity
of the myocardium does not represent the initial causal event of impaired
cardiac function. The nonischemic failing heart, in its early phases of
decompensation, has a number of myocytes that often exceeds the
number of cells in a normal heart. Alternatively, the modest reduction in
myocyte number chronically is not consistent with the severe
deterioration in ventricular performance.
In embryonic and early postnatal life.