الفهرس 
PREECLAMPSIAOnly 14 pages are availabe for public view
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Abstract
A prospective study was designed to test validity of maternal serum matrix metalloproteinase-9 as predictive of the development of preeclampsia in primigravida done at 18-20 weeks of gestation.
Pregnancy can induce hypertension in normotensive women or aggravate already existing hypertension.
The cause of the development of pregnancy-induced hypertension is unknown. The possibility that immunological as well endocrinological and genetic mechanisms are involved in the genesis of PE.
It is very important to stress on antenatal care as the first line of defense mechanism against many maternal diseases including hypertensive disorders of pregnancy, improving early diagnosis and picking up the disease with subsequent early management and intervension.
Several methods have been proposed in the prediction of PE including non-laboratory methods as parity, family and past history, as well as several laboratory investigations.
Matrix metaaloproteinase-9 has been proposed as a screening test for PE.MMP-9 now offers obstetricians the potential to exclude PE when its value above 5 by 100%, while when its value below 5 a confirmatory test is needed.
Studies on MMP-9 have shown that matrix metalloproteins inducer may serve as an important indicator in predicting PE.Ohers suggest that there may be a genetically determined mechanism of MMP-9,which protects women against PE.
In a study,the decreased expression of MMP-9 in preeclamptic placentae may lead to impaired invasion of trophoblast cells,causing abnormal placentation and occurrence of PE which is consistent with another study suggesting that MMP-9 plays a role in the pathophysiology of gestational hypertension.
This study included 120 pregnant women; 60 women of them were at high risk for development of PE,and the other 60 women were at low risk.The candidates were followed up from 18-20 weeks of gestation till delivery and subjected to the study investigations,including measurement of MMP-9.the results of this study showed that using MMP-9 as a predictor of PE is considered better negative test than positive.