الفهرس 
HISTORICAL PERSPECTIVEOnly 14 pages are availabe for public view
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Abstract
The impact of dialysis on insulin resistance was revealed first in HD patients (Foss et al., 1996). Predialytic studies have confirmed higher plasma glucose level (arterial and venous); decreased forearm muscle glucose uptake and diminished nonoxidative glucose metabolism compared to normal individuals. After at least one month of dialysis treatment, significant improvement in forearm glusoce uptake and nonxidative glucose metabolism were observed, though levels were still well below the values for healthy persons. Glucose oxidation in muscles was not significantly different between groups either in the predialytic or in the dialytic period (Foss et al., 1996). Several other studies have confirmed that HD treatment significantly improves insulin resistance (Kobayashi et al., 2000 and Mak, 1996).
The effect of PD treatment on insulin resistance is an important issue, because glucose loading during this dialysis modality could affect and worsen insulin sensitivity. Both continuous ambulatory peritoneal dialysis (CAPD) and continuous cycler-assisted peritoneal dialysis (CCPD) are shown to improve insulin resistance in uremic patients (Kobayashi et al., 2000 ).
Comparing the effect of PD and HD treatment, it was found that the CCPD group has significantly higher insulin sensitivity compared to the HD group, while the CAPD group was similar to HD (Mak, 1996).
A possible explanation could be the difference in age (young adolescents on CCPD vs 30-79 year old patients on CAPD), and to the different PD modalities.