الفهرس | Only 14 pages are availabe for public view |
Abstract Due to their high electrophlicity of bB-aroyl acrylic react readily with nuclophiles, including active methylene compounds affording either cyclic or normal Michael addition products.The present work is devoted to study the interaction of 4-(4-acetoaminophenyl)-4-oxo-but-2-enoic acid (1) with carbon nucleophilic cyclohexanone,cyclopentanon,ethyl cyanoacetate and ethyl acetoacetate in ethanol in the presence of NaOH (50%) Michael addition to afforded compounds (2a-e).On the other hand, when compound 1 was allowed to react with cyclohexanone in the presence of ammonium acetal to give compound (3).Interaction of the acid 1 with highly and moderately reactive hydrocarbons e.g p-xylene and acetanilide in the presence of anhydrous aluminum chloride under friedel-crafts reaction condition afforded (4a-b).Thus , when acid 1 was allowed to react with benzyl amine in dry benzene yielded(5) |