الفهرس | Only 14 pages are availabe for public view |
Abstract Several previous studies suggested that microalbuminuria, the early phase of diabetic nephropathy is associated with increased risk of cardiovascular morbidity and mortality, but the mechanism of this association is not clear. The aim of this work was to study prothrombin F 1 +2 in IDDM with and without microalbinuria. This work was conducted on 30 cases of IDD patient classified as follow: 15 IDD patient with microalbuminuria and 15 IDD patient without microalbuminuria and 10 apparently healthy subjectes surved as a control group. All the subjects were examined and investigated as follows: 1- Complete urine analysis. 2- Fasting and post prandial blood sugar. 3- Serum Urea and creatinine. 4- Assay of A.E.R.by microalb. immunoturbidimetric method. 5- Assay of prothrombin F 1 +2 by ELISA using enzygions F 1 +2 micro. 6- Routine coagulation study: PT, PTT, TCT and Platelets count. Our results found that Fl +2 show higher levels in cases of IDDM with microalb. than IDDM without microalb. Positive correlation between Fl+2 and A.E.R. was observed in group 1 (Microalb.), as well as group 2 (norrnoalb.). Also positive correlation between Fl +2, age, duration of disease and blood glocuse (fasting and post brandial). |