الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Breast cancer is the most frequently diagnosed cancer worldwide. It is the commenst cause of death in women. Several studies suggested that some types of viruses especially Human Papilloma virus might be involved in the pathogenesis of breast cancer. Viruses developed numerous ways to evade the host immune system. For example, HPV is able to block Fas mediated apoptosis. Several studies found that cancer cells positive for HPV are resistant to apoptosis. Fas/FasL is the major regulator of apoptosis which is involved in cancer cell death by the immune system. In spite of that it was found that breast cancer cells are resistant to apoptosis. The aim of this study was to detect the presence of HPV type 16 in breast carcinoma by targeting the E6 region and to assess Fas and FasL expression along with evaluating their correlation with clinicopathological parameters in breast carcinoma. This retrospective study comprised 45 formalin fixed paraffin-embedded tissue specimens of breast lesions. They were divided into two groups: Group I (malignant breast lesions): It included thirty cases of invasive breast carcinoma. Group II (benign breast lesions): It included fifteen cases with benign breast lesions. We found a significant down-regulation of Fas expression and up-regulation of FasL expression in invasive breast carcinomas versus benign breast. Summary and Conclusions - 161 - -There was no significant relation between age of patients and Fas, FasL and HPV-16. - There was a significant inverse relation between tumor size and Fas and no significant relation with both FasL and HPV-16. - There was a significant direct relation between ER status and Fas and a significant inverse relation with both FasL and HPV-16. - There was a significant inverse relation between PR status and HPV-16 and no significant relation with both Fas and FasL. -There was a significant inverse relation between tumor stage and Fas and a significant direct relation with both FasL and HPV-16. -There was a significant inverse relation between L.N status and Fas and a significant direct relation with both FasL and HPV-16. -There was a significant inverse relation between tumor grade and Fas and a significant direct relation with FasL and no significant relation with HPV-16. -There was a significant direct relation between Her/2 neu and HPV-16 and non significant relation with both Fas and FasL. -There was a significant inverse linear correlation between Fas and FasL expression as well as a significant inverse linear correlation between Fas expression and HPV-16 in breast carcinoma. |