الفهرس | Only 14 pages are availabe for public view |
Abstract Study the effect of iron overload on blood homeostasis as well as oxidative stress that may be induced in liver tissue and evaluate the protective and antioxidant properties of the aqueous extracts of green tea or licorice. Using the experimental iron overload model in the present work has demonstrated a positive correlation between free iron and the formation of oxidative damage in liver tissue. The consequence of such damage provides an account of some of the initiating factors or early events in hepatocellular damage that may lead to the pathological manifestations and biochemical changes (elevated lipid profile and impaired both kidney and liver functions) observed in chronic iron overload conditions. The eo administration of the two tested extracts with excess iron elicited a lowering effect on lipid peroxide product (MDA); the more potent lowering effect was displayed by licorice extract. The concomitant oral administration of green tea and licorice aqueous extract elicited protective effects indicated by the recovery that induced in both liver and kidney functions as well as the reduction of lipid profile. Green tea and licorice aqueous extracts in iron overloaded rats were not seemed to be effective on hepatic antioxidant enzymes (GSHPx and total SOD). However licorice extract administration evoked a mild elevation in hepatic GSH content. |