Search In this Thesis
   Search In this Thesis  
العنوان
Studies on some reactions with pyrimidines
المؤلف
Abd-El aal Salim, Rehab Mohamed Saber
هيئة الاعداد
باحث / رحاب محمد صابر عبد العال سالم
مشرف / ا.د / محمد جمعة محمد عاصي
مشرف / ا.د / عبد الجليل السيد عبد الرحمن عمرو
مشرف / ازد / احمد حسين مصطفى
تاريخ النشر
2010
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة الزقازيق - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

from 145

from 145

Abstract

Reaction of pyrazolone derivatives (1a-g) with peracetylated glucose under microwave irradiation for 0.5-5.0 min. using silica gel as a solid support gave the corresponding N2-nucleoside (2a-c). While their acyclonucleoside derivatives (4a-c) and (6a-d) were obtained by its reaction with 4-bromobutylacetate and 2-acetoxyethoxymethyl bromide under conventional condition in presence of DMF/K2CO3 at room temperature. The deacetylation of these cyclic and acyclic nucleoside in presence of Et3N/MeOH and few DROPs of water gave the corresponding free nucleoside (3a-c), (5a-c) and (7a-d). The structure of the new compounds was confirmed by using IR, and 1H, 13C NMR spectra and microanalysis. Selected members of these compounds were screened for antimicrobial activity