الفهرس 
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Abstract
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SUMMARY
Pregnancy has been described as a successfu11 allograft
of foregin tissue and the role of immune reactions
in human reproduction is recieving increasing attentions.
Recently. data accumulated on depression of cell-mediated
immunity during pregnancy, but still little is known about
humoral immunity in pregnancy.
Five types of immunoglobulins are are present in
human sera. These are IgG. IgM. IgA.-IgD and IgE. IgG.
IgM and IgA are the classes of immunoglobulins with antibody
activity. IgG passes through the placental barrier from
the mother to the fetus. The newborn entirely depends upon
its stock of IgG recieved through the placenta for its
protection against infection during early postnatal period
There has been a considerable debate as to whether,
or not. certain pathological conditions of pregnancy, particularly
preeclampsia are associated. either as cause or effect
with changes in the maternal antibody response.
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The purpose of the present study was to asses the
immunoglobulin concentrations in maternal and neonatal
sera in .normal and toxemic pregnancies •
Immunoglobulins Ige. IgM. IgA. IgD and IgE were
estimated in 20 women with normal pregnancy. 10 patients
suffering from preeclampsia and 10 from eclampsia. In
addition. IBe and IgM were determined in their neonates.
Observations were made regarding immunoglobulin concentrations
in relation to severity of toxaemia.
It was noted that there was significant reduction
in IBe and IgD levels in mothers suffering from preeclampsia.
with further reduction in those w1th eclampsia. On the
other hand. the IgM. and IgA levels showed no significant
change in women with pregnancy toxaemia compared to normal
pregnant ones. The IBE level was found to increase in patients
with eclampsia compared to normal control group •
Regarding the neonates. we found that there was
a significant reduction in Ige level in infants born to
toxemic mothers compared to infants born to normal pregnant
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mothers. There was also a decrease in 19M level in infants
born to mothers suffering from pregnancy toxaemia. but the
decrease was significant only in infants born to eclamptic
mothers.