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Abstract
The etiology is not fully understood why or how abnormal scars occur. Skin trauma appears to be the most common predisposing factor although keloid can occur without definitive causes. Skin and/or muscle tension seem to contribute to keloid formation and this is demonstrated by the most common sites of their formation in the upper arm and back Infection at a wound site, repeated trauma to the same area, skin tension or a foreign body in a wound and genetic predisposition can contribute to abnormal scar pathogenesis The aim of the present work is to investigate the participation of TGFβ in the pathogenesis of keloid and hypertrophic scar through immunohistochemical evaluation of TGFβ expression in scar and normal tissue This study was performed on 30 patients presented with keloid or hypertrophic scars (16 keloid & 14 hypertrophic scars). The diagnosis was made on clinical basis supported by histopathology and all patients had received neither topical nor surgical treatment for at least 2 weeks before skin biopsy. Ten age and sex matched apparently healthy volunteers were also included in this study as a control group.