الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
E- cadherin, a cell adhesion molecule that play a critical role cell-cell at matrix interaction, has recently been associated with tumor invasion and metastasiscathepsin D is an asparty llysosomal proteasae, which is widely expressed in all cells throughout thebody. We analyze the expression of E-cadherin and cathepsin significance. Fafty TUR and cystectomy bladder carcinoma sections immunohistochemicaly stained with E-cadherin and cathepsin D antibody were microscopically interpreted and results were correlated the histopathologically type tumor cell grade, tumor stage and bilharzias association. Histopathologically, 74% were transitional cell grade, tumor stage and bilharzias association. Histopathological type, tumor cell grade tumor stage and bilharzias association. histopathologically,74% were transitional cell carcinoma,13% were squamous cell carcinoma. Loss of Ecadherin had a significant association with tumor grade p=0.0001, tumor stage p+0.003, and Bilharzias-associated bladder cancer p=0.008 There was no statistically significant association between loss or decrease of e-cadherin expression and histopathological type of urinary bladder carcinoma.
Bladder cancer is a world wide problem. It is linked to chemical agents as well as cigarette smoking. In third world countries , it is linked to chronic infection with schistosomiasis . because of these links, bladder cancer has served as an excellent model for the study of cancer. Carcinoma of the urinary bladder is one of the most common malignant neoplasms in Egypt. It constitutes 30.3% of all cancers, and 40% of male cancer. The incidence of the transitional cell carcinoma is increasing while there is reduction in the incidence of the squamous cell carcinoma due to decline in the prevalence of billarziasis.