الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
The p53 gene located on chromosome 17p 13.1 and coding for a nuclear 393 amino acids phosphoprotein acts to antagonize cell growth, and as such is a tumor suppressor gene. Inactivation of the p53 gene is a common feature in the development of all or most types of human cancer. In some circumstances in response to DNA damage , the p53 level is increased considerably and induces a cell growth arrest late in G1 phase. This cycle arrest allows the altered DNA to be repaired before entry to the S phase. Thus, wild-type p53 helps the genomic stability of the cells in addition to its role in triggering apoptosis.