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العنوان
The P53 Tumour Suppressor Gene as A Common Cellular Target in Childhood Lymphoma and Leukemia /
الناشر
Ahlam Mohamed Ismail,
المؤلف
Ismail, Ahlam Mohamed
هيئة الاعداد
باحث / Ahlam Mohamed Ismail
مشرف / Amal Abd EL Salam Soliman
مشرف / Nabil Gamil Mohamed
مشرف / Abd EL Megid Abo EL Maged Abd EL Megid
الموضوع
Pediatrics Childhood Acute Leukemia Childhood Acute Lymphoplastic Leukemia The P53 Tumour Suppressor Gene Pediatrics The P53 Tumour Suppressor Gene Childhood Acute Leukemia Childhood Acute Lymphoplastic Leukemia
تاريخ النشر
1996 .
عدد الصفحات
163 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/1996
مكان الإجازة
جامعة المنيا - كلية الطب - طب الأطفال
الفهرس
Only 14 pages are availabe for public view

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from 185

Abstract

Aim of the work
To determine serum P53 protein expression in children with acute lymphoplastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL) and detect the association between the level of P53 protein expression and clinical as well as laboratory parameters.
Conclusion
- P53 protein expression ascribes an important role in children with ALL and NHL.
- P53 protein expression has a prognostic role for follow up cases with ALL and NHL.
- No role for age or FAB classification in P53 protein expression in cases of ALL.
Recommendations
Demonstration of serum P53 protein level has an important role in children with acute lymphoblastic leukemia and non Hodgkin’s lymphoma and can be used as a prognostic factor for follow up these cases. So, trials and researches about P53 tumor suppressor gene and its protein products should be done. Further studies must be done to prove the role of P53 gene in management of malignancies as a gene therapy.