الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
Immobilization and water immersion as a restraint tech— nique was used for the induction of gastric ulcerations in the albino rats. The sensitivity of the non—glandular runienal part of the stomach (fundus) to different agonists like histamine, serotonin and acetyloholine was tested in intact or surgically modified rats. The levels of histidine decarboxylase (H.D.cj,) in the glandular stomach, diamine oxidase (DA.o.) in the small intestine and monoamine oxidase (M.A.O.) in the liver were measured under the influence of age, sex, ovarico— tomy and castration in normal and restrained rats. The following conclusions were reached:
1. In all the rats examined, immobilization and water immersion restraint technique produced 100% incidence of gastric ulceration in the glandular part of the stomach (pylorus); no ulcers or lesions were observed in the non—glandular portion (rumen or fundus).
2. On testing the sensitivity of the rat fundus,to different agonists, it was found that restraint stress completely abolished the response of the fundus towards all the levels of histamine concentrations tested. With regards to serotonin, restraint stress highly and significantly decreased the f undue response to serotonin. The response of the ftndus of castrated rat towards serotonin wa also significantly decreased when compared with the normal fundus response. Moreover, the sensi—
tivity of the fundus of restrained castrated rat to serotonin