الفهرس | Only 14 pages are availabe for public view |
Abstract It the last two decades, the control of the intensity ni duration of drug action has been of prime interest and certi to research workers in the fields of medicine and. iacy. Accordingly, the potential application of two ferent techniques, that would control drug release from ral pharmaceuticals was the aim of this investigation. In the first part of this study, the solid dispersion chique (solvent method) was utilized in the preparation different solid dispersions of the water soluble anti— aaine pheniramine aminosaJ.icylate in different types of po1ynier Eud.ragit (Bud. RLPiI, Bud. RL 100, Bud. RSPM, RS 100, BUd. L 100 and Bud. S 100). This was carried t In an attempt to prolong its duration of action by trolling its release rate, with the subsequent retarda— iti its absorption rate. ipectra of the solid dispersions prepared in this part cated the absence of molecular interaction between the and the polymer. The study of drug release from the solid dispersions ared in this part was carried out fo1lov’iug a half ‘e dissolution procedure. |