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Abstract
The objective of this study was to investigate the antioxidant ameliorative effects of vitamin E on treatment of the most deleterious side effects encountered in doxorubicin chemotherapy, cardiotoxicity and myelosupression. So, twenty four adult male albino rats of body weight 150-200 g were arranged into four groups (n= 6). Vitamin E (100 mg/kg) and after 30 minutes doxorubicin (10 mg/kg) were intraperitoneally administered. Blood samples were collected, hematological and biochemical parameters were extensively studied and the levels of aminotransferases enzymes (ASAT and ALAT) activities were evaluated. liver and heart were removed and homogenized to measure the level of TBARS. Experimental data revealed an increase in R.B.Cs. count, W.B.Cs. count, Hct. value and Hb.% and decrease in triglyceride, cholesterol, total protein and albumin levels in serum and decreased levels of TBARS in both liver and heart tissues as compared with that of control groups. Also, the level of ASAT and ALAT were decreased compared with control groups. These results, concluded that vitamin E have a good ameliorative effect in doxorubicin chemotherapy.