الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
In view of the pharmacological important of thiophene and their condensed systems. We synthesized some new thiophenes and their condensed derivatives hopping that they have significant biological activities.
Nitrosation of thiophene derivative 1 with NaNO2 in HCl gave thienotrizine 3. Heterocyclization of thiophene 1 with carbon disulfide in sodium ethoxide gave thienopyrimidine 5. The acylation of thiophene 1 with acid chloride in acetic acid gave acylated derivatives 6a-c. Cyclodehydration of compounds 6a-c in acetic anhydride gave thienopyrimidin 7a-c. Acylation of thiophene 8 with acid chloride gave acylated derivatives 9a-c. Cyclization of compounds 9a,b in H2SO4 gave oxazine derivatives 10a,b. Treatment of compound 9c with ammonium thiocyanate in ethanol gave thienylthiazole derivative 12. Acylation of thiophene 8 with maleic anhydride in dry acetone gave acylated product 13. Cyclization of compound 13 in acetic anhydride gave N-thienyl malimide 14. Addition of amino function of thiophene 8 to benzoylisothiocyanate gave thiourea derivative 16. Heterocyclization of compound 16 in dry acetone gave thienopyrimidine 17. Condensation of thiophene 8 with benzaldhyde in ethanol gave Chief base 18. Cycloaddition of compound 18 with benzoylisothiocyanate gave oxadiazine derivative 19. Treatment of thiophene 20 with ethylcyanoacetate gave thienooxazine derivative 22. Acylation of thiophene 20 with maliec anhydride gave acylated product 23. Cyclization of compound 23 in acetic anhydride gave N-thienylmaleimide 25. Acylation of thiophene 20 with chloroacetyl chloride gave amide 26. Treatment of compound 26 with ammonium thiocyanate gave N-thienylthiazole derivative 28. Addition of amino function of thiophene 20 to aroylisothiocyanate gave thiourea derivative 29a,b. Heterocyclization of compound 29a,b in ethanolic ethoxide affording thienopyrimidine 30a,b. The structures were confirmed by using IR and 1H, 13C NMR spectra and microanalysis.