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Abstract
The aim of this study was to determine the expression of tumor suppressor gene Gravin which belongs to the A kinase anchoring protein family in acute leukaemia patients samples and to explore its possible prognostic importance. In this study real time quantitative PCR was used to determine Gravin gene expression and β Actin was used as control gene. Gravin gene expression was found to be decreased in 100%of patients as compared with control group and it was found that there is significant correlation between its expression and laboratory prognostic markers, prognosis and treatment outcome of acute leukemia patients.